Core Technology

At the heart of our technology lays a CMOS semiconductor microchip, or “smart chip”, called the NanoChip® Electronic Microarray – a tiny, silicon chip electronic microarraycapable of rapid identification and precise analysis of biological molecules. The microarray is housed within a cartridge.

The NanoChip® Cartridge

The NanoChip® Cartridge

There are 400 test sites available on the NanoChip® microarray, with each test site individually controlled by 12 electrical connections, which allow users to design and run multiple and diverse molecular tests. Additionally, the smart chip technology allows for memory of which test sites have been previously used.

Each test site consists of the silicon CMOS circuitry, platinum electrode and permeable gel layer. Digital commands are sent to indicate which individual test sites are to be activated by applying a positive or negative charge.

Molecules, including DNA and RNA, have natural positive and negative charges. With electricity, it is possible to facilitate both rapid movement to and from – and concentration at – designated test sites on the chip.

At the chip surface the permeable gel layer covering the chip contains streptavidin, which is utilized to noncovalently attach biotinylated DNA molecules (or capture oligonucleotides) to the test site. The strength of this streptavidin-biotin bond allows the amplicon to remain attached to the activated test site while excess amplicons (PCR products) are washed away, preventing cross contamination.

Sandwich Hybridization assays at each test are processed automatically and read by a built-in image sensor and the results are analyzed and presented.

NanochipXL technology explained

NanochipXL technology explained

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